QseC Inhibitors as an Antivirulence Approach for Gram-Negative Pathogens
ABSTRACT Invasive pathogens interface with the host and its resident microbiota through interkingdom signaling.The bacterial receptor QseC, which is a membrane-bound histidine sensor kinase, responds to the host stress hormones epinephrine and norepinephrine and the bacterial signal AI-3, integrating interkingdom signaling at the biochemical level.